| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8684089 | Epilepsy Research | 2018 | 9 Pages |
Abstract
The results of the present study demonstrate that PTEN-mTOR is the target of miR-21-5p in a kainic acid model of epilepsy. The knockout of miR-21-5p decreases the neuronal damage in stages of epileptogenesis. The miR-21-5p/PTEN/mTOR axis may be a potential target for preventing and treating seizures and epileptic damage.
Keywords
TIMP3TLEPFAMWMIPIRT-PCRmTORPDCD4GAPDHInitial precipitating injuryFDRRECKkainic acidElectroencephalogramSDS-PAGESodium dodecyl sulfate polyacrylamide gel electrophoresisstatus epilepticusEpilepsyanalysis of varianceANOVANeuron damagestandard error of the meandentate gyrustemporal lobe epilepsyphosphatase and tensin homologMorris water mazeSEMprogrammed cell death 4UTR یا untranslated regions untranslated regionTissue inhibitor of metalloproteinase-3false discovery rateEEGreverse transcription polymerase chain reactionparaformaldehydePtenglyceraldehyde-3-phosphate dehydrogenase
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Chongyang Tang, Yunhe Gu, Haiyang Wang, Hongmei Wu, Yu Wang, Yao Meng, Zhibin Han, Yifei Gu, Wei Ma, Zhenfeng Jiang, Yuanyuan Song, Meng Na, Dunyue Lu, Zhiguo Lin,