Activation of NPY-Y2 receptors ameliorates disease pathology in the R6/2 mouse and PC12 cell models of Huntington's disease

Article ID	Journal	Published Year	Pages	File Type
8684685	Experimental Neurology	2018	59 Pages	PDF

Keywords

TBS NGS SGZ eGFP i.p MSNs Aβ p38 NGF mRNA TNF-alpha DARPP-32 IκB PFA NPY ABC DAPI DMEM CREB NF-κB p150glued Machado Joseph disease PBS DAB, 3 JNKs LPS MJD mHTT FAM IκK Yrs RPM SVZ 4′,6-diamidino-2-phenylindole BDNF BSA cDNA MAPK/ERK Dulbecco's modified Eagle's medium bovine serum albumin complementary deoxyribonucleic acid interleukin Beta-amyloid Huntington's disease Tris-buffered saline Immunomodulation intraperitoneal dynactin messenger ribonucleic acid blood brain barrier BBB horse serum revolutions per minute normal goat serum PC12 cells brain derived neurotrophic factor nerve growth factor lipopolysaccharide Avidin-biotin complex Neuroprotection Phosphate-buffered saline subgranular zone subventricular zone R6/2 mice medium spiny neurons wild-type mutant Huntingtin polymerase chain reaction PCR paraformaldehyde cAMP response element binding protein enhanced green fluorescence protein Propidium iodide carboxyfluorescein UPS Neuropeptide Y

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Activation of NPY-Y2 receptors ameliorates disease pathology in the R6/2 mouse and PC12 cell models of Huntington's disease

Authors

Oluwaseun Fatoba, Eugen Kloster, Christiane Reick, Carsten Saft, Ralf Gold, Jörg T. Epplen, Larissa Arning, Gisa Ellrichmann,