| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8684708 | Experimental Neurology | 2018 | 13 Pages |
Abstract
Excessive glutamate causes over-stimulation of GluN1/GluN2B NMDA receptors and mGluR1, which in turn contributes to the calcium overload and cell death. Blockage of GluN1/GluN2B NMDA receptors and mGluR1 using combination therapy of Ifenprodil and JNJ16259685 has additive efficacy against SAH-induced neurological deficit and neuronal apoptosis.95
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Authors
Zongyong Zhang, Junke Liu, Cundong Fan, Leilei Mao, Rongxia Xie, Suyun Wang, Mingfeng Yang, Hui Yuan, Xiaoyi Yang, Jingyi Sun, Jian Wang, Jiming Kong, Siluo Huang, Baoliang Sun,