Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8684986 | Journal of Clinical Neuroscience | 2018 | 4 Pages |
Abstract
Here, we report a case of a young man, who presented with headache. Gadolinium-enhanced magnetic resonance imaging demonstrated massive lesions in the cerebrospinal fluid space, which strongly suggested leptomeningeal dissemination of a brain tumor. The histology showed the tumor comprised densely packed, small cells with scant cytoplasm. Immunoreactivities were positive for synaptophysin and chromogranin A, and negative for glial fibrillary acidic protein, S-100, EMA, and CD20. Because the tumors were located in multiple sites and most of them were within the cerebrospinal fluid space, the primary lesion could not be determined. We diagnosed this case as 'CNS primitive neuroectodermal tumor' by the patient age and predominantly supratentorial distribution of the lesions. After the induction therapy, WHO published its updated classification in 2016. Considering the possibility that the diagnosis is medulloblastoma, we performed additional immunohistochemical analyses, and diagnosed Group 3 medulloblastoma because of the expression of natriuretic peptide receptor 3.
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Authors
Hirotomo Tanaka, Daisuke Yamamoto, Mitsuru Ikeda, Masashi Morikawa, Kayo Ueda, Kazuhiro Tanaka, Takashi Sasayama, Eiji Kohmura,