Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8685328 | Journal of Clinical Neuroscience | 2018 | 5 Pages |
Abstract
Recent studies revealing genetic connection of primary open angle glaucoma (POAG) and amyotrophic lateral sclerosis (ALS) have received particular attention. Exploring the evidence for common pathogenesis of these two progressive neurological disorders may assist in understanding the mechanism and searching for new treatment. Retinal nerve fiber layer (RNFL) defect and corresponding visual field (VF) impairment are well known neuropathy signs in glaucoma. In our study, thickness of certain retinal layer in ALS patients was analyzed to detect ganglion cell's soma and axon, and for first time visual field was examined for ALS. The correlation of retinal involvement and ALS progression were also investigated. The results were compared with those of POAG. The study may provide new knowledge for these two neurodegenerative diseases.
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Neuroscience
Neurology
Authors
Ziyuan Liu, Hongli Wang, Dongsheng Fan, Wei Wang,