Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8686435 | Neurobiology of Disease | 2018 | 30 Pages |
Abstract
Our results indicate that a robust pro-inflammatory microglial phenotype/brain milieu commenced within 24Â h after LPS exposure and persisted through PND5 and in vivo TSPO binding was found at PND14-17. This suggests that there may be a window of opportunity to treat after birth. Therapies aimed at inducing an anti-inflammatory phenotype in microglia might promote recovery in maternal inflammation induced neonatal brain injury.
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Authors
Zhi Zhang, Amar Jyoti, Bindu Balakrishnan, Monica Williams, Sarabdeep Singh, Diane C. Chugani, Sujatha Kannan,