| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8686484 | Neurobiology of Disease | 2011 | 10 Pages |
Abstract
⺠Substance P (SP) is able to reduce significantly in G93A cortical neurons the kainate-induced currents and the mEPSCs. ⺠The effect is blocked by GR 82334, a NK1 competitive antagonist of SP receptor. ⺠Western blot and immunocytochemistry analysis indicate a higher NK1 expression level in G93A compared to Control cultures. ⺠Toxicity experiments reveal that SP is able to rescue G93A cortical neurons to a greater extent than Control neurons. ⺠The indication of a protective role of SP in the G93A mouse suggests an use of SP as a clinical therapeutic treatment.
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Authors
Silvia Caioli, Livia Curcio, Massimo Pieri, Alessia Antonini, Roberta Marolda, Cinzia Severini, Cristina Zona,