Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8686485 | Neurobiology of Disease | 2011 | 14 Pages |
Abstract
⺠Rotenone promotes functional impairments in the rat retina. ⺠Rotenone induces photoreceptor cell death. ⺠Rotenone induces a loss of synaptic connectivity in the outer plexiform layer. ⺠Rotenone severely impairs the retinal dopaminergic system
Keywords
COXPKCαOPLONLINLIPLGCLMPTPERG1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineROSPesticideelectroretinogramParkinson diseasetyrosine hydroxylaseretinal degenerationRotenonecytochrome c oxidaseRetinaPhotoreceptorouter plexiform layerouter nuclear layerinner plexiform layerinner nuclear layerganglion cell layerMitochondriaDopaminergic neuronParvalbumincalbindinReactive oxygen species
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Authors
Julián Esteve-Rudd, Laura Fernández-Sánchez, Pedro Lax, Emilio De Juan, José MartÃn-Nieto, Nicolás Cuenca,