| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8686487 | Neurobiology of Disease | 2011 | 9 Pages |
Abstract
⺠We propose a link between alterations of brain cholesterol homeostasis and BACE1. ⺠We utilized high-fat fed rats and high cholesterol-treated SK-N-BE cells. ⺠In both models we observed an increased expression of SREBP2 and BACE1. ⺠SREBP2 is able to bind BACE1 promoter and directly induce its expression. ⺠Changes in brain cholesterol represent a risk for BACE1 activation.
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Authors
Raffaella Mastrocola, Michela Guglielmotto, Claudio Medana, Maria Graziella Catalano, Santina Cutrupi, Roberta Borghi, Elena Tamagno, Giuseppe Boccuzzi, Manuela Aragno,