Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8686887 | NeuroImage | 2018 | 53 Pages |
Abstract
We found that motor cortical activity measured by TMS-EEG varied across time in the affected hemisphere. An increase of TMS-evoked activity was evident at 40 days after stroke onset. Moreover, stroke patients showed a significant increase in TMS-evoked alpha oscillations, as highlighted performing analysis in the time-frequency domain. Notably, these changes indicated that crucial mechanisms of cortical reorganization occur in this short-time window. These changes coincided with the clinical improvement. TMS-evoked alpha oscillatory activity recorded at baseline was associated to better functional recovery at 40 and 60 days' follow-up evaluations, suggesting that the power of the alpha rhythm can be considered a good predictor of motor recovery. This study demonstrates that cortical activity increases dynamically in the early phases of recovery after stroke in the affected hemisphere. These findings point to TMS-evoked alpha oscillatory activity as a potential neurophysiological markers of stroke recovery and could be helpful to determine the temporal window in which neuromodulation should be potentially able to drive neuroplasticity in an effective functional direction.
Keywords
BBSSSQOLTMSTMS-evoked potentialTMS-EEGTEPFMANIHSSRMTMEPMCAICAPPCFugl-Meyer AssessmentEORresting motor thresholdgamma-aminobutyric acidElectroencephalographyMRIIndependent component analysisTranscranial magnetic stimulationCortical excitabilityMagnetic resonance imagingRecoveryStrokeBarthel indexmiddle cerebral arteryOscillatory activityMotor cortexprimary motor cortexposterior parietal cortexParietal cortexNational Institutes of Health stroke scaleBerg balance scaleEEGmotor-evoked potentialQuality of Life ScaleGABA
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Authors
Maria Concetta Pellicciari, Sonia Bonnì, Viviana Ponzo, Alex Martino Cinnera, Matteo Mancini, Elias Paolo Casula, Fabrizio Sallustio, Stefano Paolucci, Carlo Caltagirone, Giacomo Koch,