Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8687522 | NeuroImage: Clinical | 2018 | 9 Pages |
Abstract
FTD mutation carriers can be separated from controls with a modest AUC even before symptom-onset, using a newly created carrier-control classification model, while this was not possible using a recent bvFTD classification model. A multimodal MRI-based classification score may therefore be a useful biomarker to aid earlier FTD diagnosis. The exclusive selection of white matter features in the best performing model suggests that the earliest FTD-related pathological processes occur in white matter.
Keywords
DWIPCORMultimodal MRIAxDWMDMAPTMMSEDTITBSSICAC9orf72GMDROCAUCaxial diffusivityResting-state functional MRItract-based spatial statisticsradial diffusivityIndependent component analysisdiffusion-weighted imagingdiffusion tensor imagingClassificationfrontotemporal dementiagrey matterwhite mattermean diffusivityarea under the receiver operating characteristics curveMini-Mental State Examinationfractional anisotropyreceiver operating characteristicsmicrotubule-associated protein tauProgranulinchromosome 9 open reading frame 72GRNMachine learning
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Authors
Rogier A. Feis, Mark J.R.J. Bouts, Jessica L. Panman, Lize C. Jiskoot, Elise G.P. Dopper, Tijn M. Schouten, Frank de Vos, Jeroen van der Grond, John C. van Swieten, Serge A.R.B. Rombouts,