| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8687590 | NeuroImage: Clinical | 2018 | 8 Pages |
Abstract
The SCA3 metabolic profile reflects network-level alterations which are primarily associated with the motor features of the disease. Striatum decreases additional to cerebellar hypometabolism underscores an intrinsic extrapyramidal involvement in SCA3. Cerebellar-posterior parietal hypometabolism together with anterior parietal (sensory) cortex hypermetabolism may reflect a shift from impaired feedforward to compensatory feedback processing in higher-order motor control. The demonstrated SCA3-RP provides basic insight in cerebral network changes in this disease.
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Authors
Sanne K. Meles, Jelmer G. Kok, Bauke M. De Jong, Remco J. Renken, Jeroen J. de Vries, Jacoba M. Spikman, Aaltje L. Ziengs, Antoon T.M. Willemsen, Harm J. van der Horn, Klaus L. Leenders, Hubertus P.H. Kremer,