Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8687602 | NeuroImage: Clinical | 2018 | 29 Pages |
Abstract
MIR137 gene has been repeatedly reported as a schizophrenia risk gene in genome-wide association studies (GWAS). A polymorphism (rs1625579) at the MIR137 gene has been associated with both neural activation and behavioral performance during a working memory task. This study examined MIR137's associations with task-related (N-back working memory) fMRI, resting state fMRI, and diffusion tensor images (DTI) data in 177 healthy adults. We found less deactivation of the PCC in risk allele homozygotes (TT) as compared to the GT heterozygotes (cluster sizeâ¯=â¯630 voxels, cluster level PFWEâ¯<â¯0.001) during the N-back task, which replicated previous findings. Using the identified cluster within the PCC as the seed, we further found decreased functional connectivity between the PCC and the anterior cingulate cortex and its adjacent medial prefrontal cortex (ACC/MPFC) in risk allele homozygotes during both resting state (cluster sizeâ¯=â¯427 voxels, cluster level PFWEâ¯=â¯0.001) and the N-back task (cluster sizeâ¯=â¯73 voxels, cluster level PFWEâ¯=â¯0.05). Finally, an analysis of our DTI data showed decreased white matter integrity of the posterior cingulum in risk allele homozygotes (cluster sizeâ¯=â¯214 voxels, cluster level PFWEâ¯=â¯0.03). Taken together, rs1625579 seems to play an important role in both functional and structural connectivity between the PCC and the ACC/MPFC, which may serve as the brain mechanisms for the link between rs1625579 and schizophrenia.
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Authors
Zhifang Zhang, Tongjun Yan, Yanyan Wang, Qiumei Zhang, Wan Zhao, Xiongying Chen, Jinguo Zhai, Min Chen, Boqi Du, Xiaoxiang Deng, Feng Ji, Yutao Xiang, Hongjie Wu, Jie Song, Qi Dong, Chuansheng Chen, Jun Li,