| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8687695 | NeuroImage: Clinical | 2018 | 10 Pages |
Abstract
Longitudinal MRI provides evidence of progressive GM and WM changes in pGRN+ participants relative to yCTL. Structural MRI illustrates the natural history of presymptomatic GRN carriers, and may provide an endpoint during disease-modifying treatment trials for pGRN+ individuals at risk for FTD.
Keywords
GMDIFOROIILFFTDSLFDWICStaxial diffusivityradial diffusivityPresymptomaticinferior fronto-occipital fasciculusdiffusion-weighted imagingMagnetic resonance imagingNeuroimagingcorticospinal tractfrontotemporal lobar degenerationfrontotemporal degenerationLongitudinalsuperior longitudinal fasciculusinferior longitudinal fasciculusGray matterwhite mattermean diffusivityBrodmann arearegion of interestfractional anisotropyProgranulinGray matter densityGRN
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Authors
Christopher A. Olm, Corey T. McMillan, David J. Irwin, Vivianna M. Van Deerlin, Philip A. Cook, James C. Gee, Murray Grossman,