| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8687944 | NeuroImage: Clinical | 2018 | 32 Pages |
Abstract
This study supports a link between glia activation and neuronal degeneration in PLS, and suggests that these disease mechanisms can be measured in vivo in PLS. Future studies are needed to determine the longitudinal changes of these imaging measures and to clarify if MR-PET with [11C]-PBR28 can be used as a biomarker for drug development in the context of clinical trials for PLS.
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Authors
Sabrina Paganoni, Mohamad J. Alshikho, Nicole R. Zürcher, Paul Cernasov, Suma Babu, Marco L. Loggia, James Chan, Daniel B. Chonde, David Izquierdo Garcia, Ciprian Catana, Caterina Mainero, Bruce R. Rosen, Merit E. Cudkowicz, Jacob M. Hooker,