Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8688227 | NeuroImage: Clinical | 2017 | 8 Pages |
Abstract
Flutemetamol and PiB show similar topographical GM uptake in AD and CN participants and the tracers show comparable group discrimination. Greater WM accumulation with FMT suggests that quantitative differences vs. PiB will be apparent when using WM or GM as a reference region. Both imaging tracers demonstrate increased WM uptake in older people. These findings suggest that using different amyloid tracers or different methods of analyses in serial brain imaging in an individual may result in artifactual amyloid change measurements. Clinical use of several amyloid tracers in the same patient will have challenges that need to be carefully considered.
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Authors
Val J. Lowe, Emily Lundt, David Knopman, Matthew L. Senjem, Jeffrey L. Gunter, Christopher G. Schwarz, Bradley J. Kemp, Clifford R. Jr, Ronald C. Petersen,