Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8688238 | NeuroImage: Clinical | 2017 | 57 Pages |
Abstract
DSEG θ is a powerful tool for characterising subtle brain change in SVD that has a negative impact on cognition and remains a significant predictor of cognitive change when other MRI markers of brain change are accounted for. DSEG provides an automatic segmentation of the whole cerebrum that is sensitive to a range of SVD related structural changes and successfully predicts cognitive change. Power analysis shows DSEG θ has potential as a monitoring tool in clinical trials. As such it may provide a marker of SVD severity from a single imaging modality (i.e. DTIs).
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Authors
Owen A. Williams, Eva A. Zeestraten, Philip Benjamin, Christian Lambert, Andrew J. Lawrence, Andrew D. Mackinnon, Robin G. Morris, Hugh S. Markus, Rebecca A. Charlton, Thomas R. Barrick,