Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8688365 | NeuroImage: Clinical | 2017 | 10 Pages |
Abstract
As previously reported, brain regions affected by AD during its initial stages, such as hippocampus, amygdala, entorhinal cortex, and parahippocampal region, were found to be altered even in individuals with severe AD. In addition, individuals, specifically, with CDR 3, have multiple regions with lower volumes than individuals with a CDR 2. These results indicate that rates of atrophy have not plateaued out at CDR 2-3, and in severe patients there are yet neuronal loss and gliosis. These findings can add important information to the more accepted model in the literature that focuses mainly on early stages. Our findings allow a better understanding on the AD pathophysiologic process and follow-up process of drug treatment even at advanced disease stages.
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Authors
Silvio Ramos Bernardes da Silva Filho, Jeam Haroldo Oliveira Barbosa, Carlo Rondinoni, Antonio Carlos dos Santos, Carlos Ernesto Garrido Salmon, Nereida Kilza da Costa Lima, Eduardo Ferriolli, Júlio César Moriguti,