| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8688408 | NeuroImage: Clinical | 2017 | 9 Pages |
Abstract
Reduced FA of the corpus callosum in ALS results from complex changes in tissue microstructure. Callosal segments with reduced FA had large numbers of microglia-macrophages in addition to loss of myelinated axons and astrogliosis. Microglial inflammation contributed to reduced FA in ALS, and may contribute to a pro-inflammatory state, but further work is needed to determine their role.
Keywords
DWIDTI7 T MRIGFAPSNRPSIVOIaxial diffusivitySteady-state free precessionamyotrophic lateral sclerosisMRIradial diffusivityALSmotor neuron diseaseDiffusion weighted imagingdiffusion tensor imagingMagnetic resonance imagingvolume of interestPMIPost mortem intervalmean diffusivityMicrogliafractional anisotropysignal to noise ratioPathologyGlial fibrillary acidic protein
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Agustin M. Cardenas, Joelle E. Sarlls, Justin Y. Kwan, Devin Bageac, Zachary S. Gala, Laura E. Danielian, Abhik Ray-Chaudhury, Hao-Wei Wang, Karla L. Miller, Sean Foxley, Saad Jbabdi, Robert C. Welsh, Mary Kay Floeter,