Article ID Journal Published Year Pages File Type
8688720 NeuroImage: Clinical 2017 32 Pages PDF
Abstract
Quantitative measures of strength and walking are associated with brain corticospinal tract pathology. The addition of these quantitative measures to basic clinical information explains more of the variance in corticospinal tract fractional anisotropy and magnetization transfer ratio than the basic clinical information alone. Outcome measurement for multiple sclerosis clinical trials has been notoriously challenging; the use of quantitative measures of strength and walking along with tract-specific imaging methods may improve our ability to monitor disease change over time, with intervention, and provide needed guidelines for developing more effective targeted rehabilitation strategies.
Related Topics
Life Sciences Neuroscience Biological Psychiatry
Authors
, , , ,