| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8688843 | NeuroImage: Clinical | 2017 | 8 Pages |
Abstract
Using 3T MRI and longitudinal VBM we have identified key anatomical regions of progressive volume loss which correlate with an established clinical disease severity index and are relevant to clinical deterioration. Localisation of the regions of progressive brain atrophy correlating most strongly with clinical decline may help to provide more targeted imaging endpoints for future clinical trials.
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Authors
Enrico De Vita, Gerard R Ridgway, Mark J White, Marie-Claire Porter, Diana Caine, Peter Rudge, John Collinge, Tarek A Yousry, Hans Rolf Jager, Simon Mead, John S Thornton, Harpreet Hyare,