Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8688857 | NeuroImage: Clinical | 2017 | 7 Pages |
Abstract
A robust global approach considering only the voxels with a single-fiber configuration was used in addition to global analysis of the tract skeleton and probabilistic whole-brain tractography. In addition, we assessed whether the microstructural parameters correlated with age, time from injury, patient's outcome and white matter MRI hyperintensities. We found that whole-brain global approach restricted to single-fiber voxels showed significantly decreased fractional anisotropy (FA) (p = 0.002) and increased radial diffusivity (p = 0.011) in patients with mTBI compared with controls. The results restricted to single-fiber voxels were more significant and reproducible than those with the complete tract skeleton or the whole-brain tractography. FA correlated with patient outcomes, white matter hyperintensities and age. No correlation was observed between FA and time of scan post-injury. In conclusion, the global approach could be a promising imaging biomarker to detect white matter abnormalities following traumatic brain injury.
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Authors
Mehrbod Mohammadian, Timo Roine, Jussi Hirvonen, Timo Kurki, Henna Ala-Seppälä, Janek Frantzén, Ari Katila, Anna Kyllönen, Henna-Riikka Maanpää, Jussi Posti, Riikka Takala, Jussi Tallus, Olli Tenovuo,