Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8688922 | NeuroImage: Clinical | 2017 | 34 Pages |
Abstract
In patients with PD, the development of widespread changes in cortical microstructure was observed as reflected by a reduction of cortical T1. The pattern of T1 decrease in PD patients exceeded the normal T1 decrease as found in physiological aging and showed considerable overlap with the pattern of cortical thinning demonstrated in previous PD studies. Therefore, cortical T1 might be a promising additional imaging marker for future longitudinal PD studies. The biological mechanisms underlying cortical T1 reductions remain to be further elucidated.
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Authors
Lucas Nürnberger, René-Maxime Gracien, Pavel Hok, Stephanie-Michelle Hof, Udo Rüb, Helmuth Steinmetz, Rüdiger Hilker, Johannes C. Klein, Ralf Deichmann, Simon Baudrexel,