The association between intra- and juxta-cortical pathology and cognitive impairment in multiple sclerosis by quantitative T2* mapping at 7Â T MRI

Article ID	Journal	Published Year	Pages	File Type
8689050	NeuroImage: Clinical	2016	8 Pages	PDF

Abstract

Location of pathology across the cortical width and mantle showed selective correlation with impairment in differing cognitive domains. These findings may guide studies at lower field strength designed to develop surrogate markers of cognitive impairment in MS.

Keywords

TMT CVLT SDMT Symbol Digit Modalities Test WCST EDSS Digit Span Backward PCA T2*Trail Making Test California verbal learning test cognitive impairment Digit Span Forward MRI tot Principal component analysis Wisconsin Card Sorting Test Magnetic resonance imaging Neuropsychological white matter Multiple sclerosis Delayed recall

Related Topics

Life Sciences Neuroscience Biological Psychiatry

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The association between intra- and juxta-cortical pathology and cognitive impairment in multiple sclerosis by quantitative T2* mapping at 7Â T MRI

Authors

Céline MD, PhD, Sindhuja T. MS, Costanza MD, Nancy PhD, A. Scott MD, MMSc, Jacob A. MD, PhD, Revere P. MD, Caterina MD, PhD,