Inmunoglobulina endovenosa en enfermedades neuromusculares. Actualización de la guía para su utilización

In 2006 the Peripheral Nervous System Diseases' Work Group of the Argentine Neurological Society published a «Guide for the use of Intravenous Immunoglobulin (IVIG) in Neuromuscular Diseases». After 10 years, the Group presents this update, which systematically reviews the literature published from 1980 to 2015, with a uniform analysis, and recommends its use for each indication according to international criteria. These recommendations have been agreed upon by the members of the Group, adding the experience of the authors in certain specific clinical circumstances that are explicitly detailed. This paper is not intended to exclude other indications, but an Evidence-Based Clinical Practice Guide, which could help the neurologist in the treatment of diseases of the peripheral nervous system. Ten different topics related to the use of IVIG have been considered: 1) Mechanisms of action; 2) Acute Neuropathies; 3) Chronic Neuropathies; 4) Paraproteinemic neuropathies; 5) Diseases of the Neuromuscular Junction; 6) Muscle Diseases; 7) Ganglionopathies and Small Fiber Neuropathies; 8) Stiff Person Syndrome and Post-Polio Syndrome; 9) Posology and Dosage Regimen and, finally, 10) Adverse Events.