Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8691378 | World Neurosurgery | 2018 | 36 Pages |
Abstract
We reviewed recent studies on ischemic penumbra, including the evolution of the definitions of ischemic penumbra and observations on the characteristics of blood flow and the molecular evolutionary mechanism of ischemic tissues; at the same time, a brief summary of current clinical treatment methods were included. From the perspective of neuroimaging and clinical treatment, the characteristics of cerebral blood flow, oxygen consumption, cell water content, and metabolites were analyzed, to evaluate the diagnosis and evolution of ischemic penumbra. The analysis of the evolutionary characteristics of multiple gene molecules and metabolites may provide ideas for clinical imaging diagnosis and clinical treatment, also allow the combination of multiparameter imaging indexes to be more accurate and effective for the assessment of ischemic penumbra. The research hotspot of imaging on the ischemic penumbra region in the future may be more focused on reflecting the evolutionary characteristics of local metabolites in the ischemic area. Using multimodality imaging to evaluate IP zones and guide the formulation of clinical treatment protocols.
Keywords
DSCMR CLEANECASSOEFIVIMCESTTTPPWICBVmean diffusionCMRO2DWICBFDTISWIASLADCLACDKIMTTAdenosine TriphosphateATPMulticenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The NetherlandsLactic acidMRIChemical exchange saturation transferThrombolysissusceptibility-weighted imagingPerfusion-weighted imagingdiffusion-weighted imagingdiffusion tensor imagingMagnetic resonance imagingDiffusion kurtosis imagingcomputed tomographyPositron emission tomographycerebral blood flowCerebral blood volumeIntravoxel incoherent motionsICHsymptomatic intracranial hemorrhageEndovascular therapytime to peakIschemic penumbraSwiftNINDSapparent diffusion coefficientarterial spin labelingMean kurtosisEuropean cooperative acute stroke studyNational Institute of Neurological Disorders and StrokeMean transit timeCerebral metabolic rate for oxygenfractional anisotropyodds ratioPETPerfusionoxygen extraction fractiondynamic susceptibility contrast
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Authors
Yun-Cai Ran, Ming Zhu, Shu-Jian Li, Zan-Xia Zhang, Xiao Wang, Yong Zhang, Jing-Liang Cheng,