Chemical constituents and pharmacological effects of genus Engelhardia

Engelhardia Leschen. ex Blume (Juglandaceae) is native to southern and southeastern Asia and used to be traditional medicines and health tea. Hitherto, a large amount of chemical constituents had been isolated from genus Engelhardia and more pharmacological effects were found due to the presence of the second metabolites. There have been few comprehensive reports about Engelhardia plants especially the chemical constituents by now. The traditional usage of Engelhardia plants were for treating cold fever, detoxication, rheumatism, diarrhea, obesity, gastrointestinal problem and so on. While the modern pharmacological activities showed antioxidant activity, anti-ischemia/reperfusion injury, anticancer activity, anti-inflammatory activity, immunosuppression activity, antidiabetic activity, antitubercular activity and so on. In this review, constituents of this genus would be introduced and classified by structures, the pharmacological effects of which would be described as well.