Article ID Journal Published Year Pages File Type
869596 Biosensors and Bioelectronics 2009 5 Pages PDF
Abstract

We present the design, fabrication and optical investigation of photonic crystal (PhC) nanocavity drop filters for use as optical biosensors. The resonant cavity mode wavelength and Q  -factor are studied as a function of the ambient refractive index and as a function of adsorbed proteins (bovine serum albumin) on the sensor surface. Experiments were performed by evanescent excitation of the cavity mode via a PhC waveguide. This in turn is coupled to a ridge waveguide that allows the introduction of a fluid flow cell on a chip. A response of ∂λ/∂c=(4.54±0.66)×105∂λ/∂c=(4.54±0.66)×105 nm/M is measured leading to a measured detection limit as good as Δm=4.0±0.6 fg or Δm/ΔA=(4.9±0.7)×102 pg/mm2in the sensitive area.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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