| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8696304 | American Journal of Orthodontics and Dentofacial Orthopedics | 2017 | 9 Pages |
Abstract
We observed enhanced expression of IL-6 and its key signaling factors gp130, STAT3, and SHP2 protein and mRNA at the tension and compression sides of the teeth with application of orthodontic forces. The mechanical loading applied for orthodontic tooth movement might induce changes in protein localization and mRNA expression patterns of IL-6 and its key signaling factors gp130, STAT3, and SHP2 at the tension and compression sides of the periodontal ligaments of the teeth in mouse models. The result might demonstrate the special role of IL-6 and its key signaling factors in the alveolar bone-modeling process.
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Authors
Yi Liu, Fang Song, Shu Wu, Shushu He, Mingmei Meng, Chunxiao Lv, Qingqing Yang, Song Chen,