Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
869681 | Biosensors and Bioelectronics | 2006 | 7 Pages |
Abstract
The array biosensor provides the capability for simultaneously measuring titers of antibody against multiple antigens. Human antibodies against four different targets, tetanus toxin, diphtheria toxin, staphylococcal enterotoxin B (SEB) and hepatitis B, were measured simultaneously in sera from eight different donors in a single assay and titers were determined. The assays could measure amounts of bound antibody as low as approximately 100 fg. Each individual serum exhibited a different pattern of reactivity against the four target antigens. Applications of this biosensor capability include monitoring for exposure to pathogens and for efficacy of vaccination.
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Maria C. Moreno-Bondi, Chris Rowe Taitt, Lisa C. Shriver-Lake, Frances S. Ligler,