Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8707636 | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | 2018 | 56 Pages |
Abstract
This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered.
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Authors
Nikolaos G. MD, DDS, PhD, Monica DDS, MSc, Maria DDS, MSc, Catherine F. DDS, PhD, FRCD(C), Douglas E. DMD, PhD, FDS, RCSEd, Paul MSc, DDS, FRCD(C), Mark DDS, PhD, FRCPath, John J. DDS, MS,