Dissociable effects of sleep deprivation on functional connectivity in the dorsal and ventral default mode networks

The present findings suggest a dissociable effect of sleep deprivation on functional connectivity in the DMN. Lower functional connectivity in dorsal DMN was related to impairments of basic cognitive function. Notably, working memory was positively correlated with the putative compensatory enhanced functional connectivity across two subsystems, which in turn correlated with behavioral performance after sleep deprivation; this suggests that good working memory may play a protective role in sleep deprivation.