Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8711542 | Annales de Dermatologie et de Vénéréologie | 2017 | 7 Pages |
Abstract
Atopic dermatitis is a multifactorial disease due to a combination of genetic and environmental factors. The pathophysiological mechanisms involved in AD are multiple: innate functional abnormality in the skin barrier partly linked to mutations of the filaggrin, a major structural protein of the skin; and genes involved in innate and adaptive immunity; Finally, the model of the hygiene theory has been clarified in recent years: environmental factors alter the diversity of skin and digestive microbiomes, and this diversity seems to play a major role in the development of atopy.
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Authors
S. Barbarot, H. Aubert,