| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8712931 | Journal of Allergy and Clinical Immunology | 2018 | 17 Pages |
Abstract
The Serpins Spi2A in mice and SERPINB3 and SERPINB4 in allergic patients control the viability of TH2 cells. This provides proof of principle for a therapeutic approach for allergic disease through ablation of allergic memory TH2 cells through SERPINB3 and SERPINB4 mRNA downregulation.
Keywords
S-Cphorbol 12-myristate 13-acetateILC2CRTH2ICSPerCPAICDBALAPCOVAProstaglandin D2 receptorILC1TCrshRNASCCAFACSPMAsmall hairpin RNASERPINGrass pollen allergyallophycocyaninSTATSquamous cell carcinoma antigenOvalbuminSerine protease inhibitorMemoryApoptosisfluorescence-activated cell sortingintracellular stainingTH2 cellsphycoerythrinbronchoalveolar lavageSignal transducer and activator of transcriptionactivation-induced cell deathknockoutPeridinin-chlorophyll-protein complexT-cell receptor
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Authors
Mohamed H. PhD, FAAAAI, Jeff N. PhD, Wei PhD, Susan M. PhD, Ellen MSc, Amy R. MSc, Natalia D.C. MSc, Fedina MSc, Fabian MSc, Stephen R. MD, Philip G. PhD,