R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome

Article ID	Journal	Published Year	Pages	File Type
8713021	Journal of Allergy and Clinical Immunology	2018	87 Pages	PDF

Keywords

WASP Th1/Th2 differentiation MNase X-linked thrombocytopenia XLT S2P DRB shRNA GFP NF-κB DDR DSB qPCR RNA polymerase II Quantitative PCR short hairpin RNA DNA damage chromatin immunoprecipitation TOP WAS Genomic instability Topoisomerase R-loops Wiskott-Aldrich syndrome double-strand break Mass spectrometry nuclear factor κB Drip Knockdown knockout wild-type micrococcal nuclease DNA damage response Wiskott-Aldrich syndrome protein green fluorescent protein CHiP primary immunodeficiency

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R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome

Authors

Koustav PhD, Seong-Su PhD, Kuo-Kuang PhD, Hans D. MD, Loïc PhD, Michael M. PhD, Yatin M. MD,