| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8713024 | Journal of Allergy and Clinical Immunology | 2018 | 48 Pages |
Abstract
Our findings emphasize involvement of the IL-12/IL-35 balance in the pathogenesis of pSS. Serum IL-35 levels were associated with low disease activity, in contrast with serum IL-12p70 levels, which were associated with more active disease.
Keywords
regulatory BSTAT4RNAseqIL-12eQTLIL-35PSSIL-12RESSDAIAssessBAFFBregExpression quantitative trait lociRNA sequencingregulatory B cellRegulatory T cellSjögren syndromeprimary Sjogren syndromeSystemic lupus erythematosusSLESignal transducer and activator of transcription 4Principal investigatorGenome-wide association studyGWASAncestry informative markerAIMSingle nucleotide polymorphismSNPIL-12 receptor
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Authors
Olivier MD, Elodie MD, Raphaèle MD, PhD, Gaetane MD, PhD, Saida BSc, Bineta BSc, Jacques-Eric MD, PhD, Véronique MD, PhD, Jean-Jacques MD, PhD, Joanne MPH, Kimberly E. MPH, PhD, Philippe MD, PhD, Philippe MD, PhD, Lindsey A. MD, MPH, DSc, Bernd PhD,