| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8713166 | Journal of Allergy and Clinical Immunology | 2018 | 46 Pages |
Abstract
Anti-IL-33 or dexamethasone suppressed the magnitude of type 2 inflammation during a rhinovirus-induced acute exacerbation; however, only anti-IL-33 boosted antiviral immunity and decreased viral replication. The latter phenotype was replicated in rhinovirus-infected human AECs, suggesting that anti-IL-33 therapy has the additional benefit of enhancing host defense.
Keywords
FITCRhinovirus 16cockroach extractTCID50PerCPAECILC2IL-33HMGB1ASMCREAsthmaBALFPVMexacerbationhigh-mobility group box 1Tissue culture infective doseairway epithelial cellAntiviralAirway smooth musclephycoerythrinfluorescein isothiocyanateBronchoalveolar lavage fluidtype 2 innate lymphoid cellplaque-forming unitRhinovirusPneumonia virus of micePeridinin-chlorophyll-protein complexpfu
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Authors
Rhiannon B. PhD, Vivian PhD, Jason P. PhD, Natale PhD, John W. MD, PhD, Kirsten PhD, Simon PhD,