| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8713167 | Journal of Allergy and Clinical Immunology | 2018 | 54 Pages |
Abstract
These data show that the extent of TNFAIP3 expression in DCs controls TH2/TH17 cell differentiation. This implies that reducing DC activation could be a new pharmacologic intervention to treat patients with severe asthma who present with TH17-mediated neutrophilic inflammation.
Keywords
NF-κBAHRCDCRNA-seqHDMTCrMoDCTNFAIP3Th17 cellsMEVBALLysMMLNYFPAsthmaRNA sequencingT-betDendritic cellTH2 cellsconventional dendritic cellDendritic cellsMonocyte-derived dendritic cellT-box transcription factor nuclear factor κBbronchoalveolar lavagebone marrowNeutrophilswild-typeAirway hyperresponsivenessyellow fluorescent proteinHouse dust miteMediastinal lymph nodeT-cell receptor
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Authors
Heleen PhD, Ingrid M. BSc, Jennifer A.C. BSc, Menno BSc, Denise MSc, Martijn J. PhD, Saravanan Y. PhD, Geert PhD, Hamida PhD, Bart N. MD, PhD, Rudi W. PhD, Mirjam PhD,