| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8713187 | Journal of Allergy and Clinical Immunology | 2018 | 59 Pages |
Abstract
Therapeutic payloads can be targeted selectively to eosinophils and malignant mast cells by exploiting this Siglec-8 endocytic pathway.
Keywords
PI3KSiglec-8ITSMITIMSFKDAPIPTP4′-6-diamidino-2-phenylindoleSrc family kinaseEndocytosisEosinophilSystemic mastocytosisImmunotoxinbisindolylmaleimide IAllergic diseasesSiglecPhosphatidylinositol 3-kinaseChronic eosinophilic leukemiaImmunoreceptor tyrosine-based switch motifMast cellBIMImmunoreceptor tyrosine-based inhibitory motifTargetingProtein tyrosine phosphatase
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Authors
Jeremy A. PhD, Daniela J. BS, Yun MS, Adriano N. MD, PhD, Bruce S. MD,