Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Article ID	Journal	Published Year	Pages	File Type
8713374	Journal of Allergy and Clinical Immunology	2018	51 Pages	PDF

Abstract

This study identifies multiple novel loci as risk factors for PA and food allergy and establishes C11orf30 as a risk locus for both PA and food allergy. Multiple genes (C11orf30/EMSY, SKAP1, and CTNNA3) identified by this study are involved in epigenetic regulation of gene expression.

Keywords

eQTL CTNNA3 EMSY Integrin α6 UFA FLG ITGA6 SKAP1 MAF CFA MMP CNV peanut allergy Food allergy Epigenetics Expression quantitative trait locus Meta-analysis minor allele frequency filaggrin matrix metallopeptidase Genome-wide association study GWAS odds ratio Copy number variant Single nucleotide polymorphism SNP quality control

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Authors

Yuka MD, MSc, Aida PhD, C. Dorien BSc, Loubna PhD, Ming BSc, George BSc, Moshe MD, MSc, David PhD, Manuel A. PhD, Katrina MD, PhD, Bruce MD, Hans MD, PhD, Nicolette W. PhD, Roy N. MD, PhD, Anthony E.J. MD, PhD, Rick MSc, Stephen MD, Joshua PhD,