| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8713482 | Journal of Allergy and Clinical Immunology | 2018 | 83 Pages |
Abstract
IL1RL1 gene expression is associated with eosinophilic SA, whereas NLRP3 inflammasome expression is highest in patients with neutrophilic SA. TH2-driven eosinophilic inflammation and neutrophil-associated inflammasome activation might represent interacting pathways in patients with SA.
Keywords
NODSASMIL-1 receptor–like 1IL1RL1NLRC4IL-33 receptorNLRP1ADEPTTh2NLRP3HDMFeNOIL-1RIL-1αAHRFDRRT-qPCRBALMMAIL-1βSANquantitative RT-PCRSevere asthmaEosinophilInflammasomeEnrichment Scoreexhaled nitric oxideFraction of exhaled nitric oxidenucleotide-binding oligomerization domainbronchoalveolar lavagefalse discovery rateneutrophilAirway hyperresponsivenessC-reactive proteinHouse dust miteIL-1 receptor
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Authors
Christos PhD, Stelios PhD, Uruj MBBS, Chih-Hsi MBBS, Coen PhD, Kirsty PhD, Kai PhD, Matthew J. PhD, Frederic PhD, Andrew L. PhD, Oluwaseun PhD, Rene PhD, Anthony PhD, Aruna PhD, Charles PhD, Ana PhD, Julie MSc, Ratko MD, Ian M. PhD,