| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8713486 | Journal of Allergy and Clinical Immunology | 2018 | 60 Pages |
Abstract
These studies support a potentially critical but previously unidentified function of the KYN/AhR axis in regulating IgE-mediated mast cell activation through ROS and ox-CaMKII in CRSwNP.
Keywords
BMMCsBone marrow–derived mast cellsTDO2IDO1CRSwNPCYP1B1CYP1A1CaMKIIOVACRSAHRPCAROSPassive cutaneous anaphylaxisOvalbuminIndoleamine 2,3-dioxygenase 1KYNChronic rhinosinusitis with nasal polypsChronic rhinosinusitisMast cellwild-typecalmodulin-dependent protein kinase IINasal polypkynurenineReactive oxygen speciesaryl hydrocarbon receptorAryl hydrocarbon receptor (AhR)
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Authors
Heng MD, PhD, Danh C. PhD, Jinxin MD, Baofeng MD, PhD, Jingjing PhD, Xia MD, Xiaoyan MD, PhD, Ho Man MS, Ho Lam PhD, Chengping MD, PhD, Mark E. MD, PhD, Zheng MD, PhD, Peisong MD, PhD,