| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8713502 | Journal of Allergy and Clinical Immunology | 2018 | 45 Pages |
Abstract
Our studies reveal that Act-A-iTreg cells instruct the generation of a highly effective immunoregulatory circuit encompassing tolerogenic DCs and forkhead box P3+ Treg cells that could be targeted for the design of novel immunotherapies for allergic disorders.
Keywords
KLF4Effector TCTLA-4BM-DCsDLNMHCIIIRF4CD62 ligandCD62LICOSTregIPABALOVAPD-L1CDCGFPPD-1FOXP3RNA-seqactivin-AMHC class IIAllergic asthmaAlumcytotoxic T lymphocyte–associated antigen 4OvalbuminIngenuity Pathway AnalysisRNA sequencingfold changeTeffforkhead box P3Dendritic cellBone marrow–derived dendritic cellconventional dendritic cellTolerogenic dendritic cellsRegulatory T cellsInterferon regulatory factor 4Transcription factorKrüppel-like factor 4bronchoalveolar lavageProgrammed death ligand 1Regulatory T Immune regulationaluminum hydroxidegreen fluorescent proteinInducible costimulatorDraining lymph nodeLymph node
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Authors
Maria PhD, Ioannis PhD, Aggelos PhD, Dimitris MSc, Marina MSc, Tim MD, Georgina PhD,