Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

Article ID	Journal	Published Year	Pages	File Type
8713925	Journal of Allergy and Clinical Immunology	2017	48 Pages	PDF

Abstract

We report that adhesion-induced eosinophil cytolysis takes place through RIPK3-MLKL-dependent necroptosis, which can be counterregulated by autophagy.

Keywords

DPI PI3K piecemeal degranulation iC3b MLKL CR3 mTOR EPX TNFR IVIg MAPK Nec-1 PMd ROS eosinophil peroxidase Autophagy HES Tem Intravenous immunoglobulin Room temperature diphenyleneiodonium chloride RIPK Hypereosinophilic syndrome phosphatidylinositol 3′-kinase Non-apoptotic cell death Transmission electron microscopy Necroptosis Necrosis Mechanistic target of rapamycin mitogen-activated protein kinase receptor-interacting protein kinase Reactive oxygen species TNF receptor Complement receptor 3

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Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

Authors

Susanne MD, Xiaoliang PhD, Elisabeth MD, Christina PhD, Beata PhD, Ruslan PhD, Dagmar MD, Peter J. PhD, Shida PhD, Hans-Uwe MD, PhD,