Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-ÎºB activation and leads to incontinentia pigmenti

Article ID	Journal	Published Year	Pages	File Type
8713931	Journal of Allergy and Clinical Immunology	2017	33 Pages	PDF

Abstract

We identified a hitherto unreported disease mechanism (defective linear ubiquitination) in patients with IP.

Keywords

EDA-ID TNF receptor–associated factor HOIP linear ubiquitination RIP1 IKBKG NF-κB TRAF IKK NEMO PLA IκB kinase incontinentia pigmenti Proximity ligation assay Sharpin nuclear factor κB LUBAC NF-κB essential modulator hemagglutinin receptor-interacting protein 1

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-ÎºB activation and leads to incontinentia pigmenti

Authors

Elodie PhD, Emmanuel PhD, Yamina PhD, Virginie PhD, Bertrand PhD, Alessandra PhD, Capucine MD, PhD, Smaïl MD, PhD, Ghislaine MSc, Julie MD, PhD, Jean-Paul MD, PhD, Valeria M. PhD, Pierre MD, PhD, Arnold MD, PhD, Jean-Laurent MD, PhD, Christine MD, PhD,