Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin

Article ID	Journal	Published Year	Pages	File Type
8715585	Journal of Dermatological Science	2018	13 Pages	PDF

Abstract

The efficacy of the MAL-PDT on AK lesions was confirmed at whole-genome gene expression level. A transcriptional signature of remodeling, identified through assessing the effect of MAL-PDT on photodamaged skin, supports the use of MAL-PDT for treating photodamaged skin and field cancerized areas.

Keywords

NTF SCC NSE OTR lesional FDR PDT UVR ECM MAL Ultraviolet radiation Remodeling Photodynamic therapy DEG Extracellular matrix methyl aminolevulinate gene expression profiling false discovery rate Differentially expressed genes Squamous cell carcinoma Actinic keratosis Organ transplant recipients

Related Topics

Health Sciences Medicine and Dentistry Dermatology

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Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin

Authors

Florence Joly, Sophie Deret, Bastien Gamboa, Corinne Menigot, Paul Fogel, Carine Mounier, Pascale Reiniche, Farzaneh Sidou, Jérome Aubert, John Lear, Anthony A. Fryer, Francesca Zolezzi, Johannes J. Voegel,