Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8720378 | Journal of Orthopaedics | 2018 | 6 Pages |
Abstract
The purpose of this study was to examine the influence of topical vancomycin on cell migration and survival of tissue healing cells. Human osteoblasts, myoblasts and fibroblasts were exposed to vancomycin at concentrations of 1, 3, 6, or 12â¯mg/cm2 for either a 1-h or 48-h (continuous) duration. Continuous exposure to all vancomycin concentrations significantly reduced cell survival (<22% cells survived) and migration in osteoblasts and myoblasts (Pâ¯<â¯0.001). 1-h vancomycin exposure reduced osteoblast and myoblast survival and migration only at 12â¯mg/cm2 (Pâ¯<â¯0.001). Further in vivo studies are warranted to optimize the dosage of intrawound vancomycin.
Related Topics
Health Sciences
Medicine and Dentistry
Emergency Medicine
Authors
James X. Liu, Dalibel Bravo, John Buza, Thorsten Kirsch, Oran Kennedy, Andrew Rokito, Joseph D. Zuckerman, Mandeep S. Virk,