Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8721343 | Clinical Immunology | 2018 | 33 Pages |
Abstract
Various preclinical studies have demonstrated that the success of immunotherapeutic strategies in inhibiting tumor progression in animal models of Glioblastoma multiforme (GBM). It is also evident that tumor-induced immune suppression drastically impacts the efficacy of immune based therapies. Among the mechanisms employed by GBM to induce immunosuppression is the accumulation of regulatory T cells (Tregs) and Myeloid derived suppressor cells (MDSCs). Advancing our understanding about the pathways regulating the expansion, accumulation and activity of MDSCs will allow for the development of therapies aimed at abolishing the inhibitory effect of these cells on immunotherapeutic approaches. In this review, we have focused on the origin, expansion and immunosuppressive mechanisms of MDSCs in animal models and human cancer, in particular GBM.
Keywords
PDL1TAMsPMNIDH1fms-like tyrosine kinase 3 ligandGBMFlt3LRNScox2atRAROSall-trans retinoic acidhuman leucocyte antigenHLAIsocitrate dehydrogenase 1immunotherapyTumor associated macrophagesT cellsMyeloid derived suppressor cellscyclooxygenase 2Programmed death ligand 1CARSTumor microenvironmentPolymorphonuclearGlioblastoma multiformeGliomareactive nitrogen speciesReactive oxygen speciesChimeric antigen receptors
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Authors
Neha Kamran, Mayuri Chandran, Pedro R Lowenstein, Maria G Castro,