Article ID Journal Published Year Pages File Type
8721658 Diabetes & Metabolism 2017 9 Pages PDF
Abstract
Our study has shown that, in αTC1 cells, Dapa acutely upregulates SGLT1 expression and increases glucagon release through an SGLT1-dependent mechanism, with SGLT2 expression virtually undetectable. These results suggest the involvement of SGLT1 in modulating glucagon increases following SGLT2 inhibition.
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Related Topics
Health Sciences Medicine and Dentistry Endocrinology, Diabetes and Metabolism
Preview
Dapagliflozin modulates glucagon secretion in an SGLT2-independent manner in murine alpha cells
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