Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8723157 | Journal of Clinical Densitometry | 2016 | 6 Pages |
Abstract
The purpose of this study was to evaluate the frequency of osteoporosis (OP) in patients with Gaucher disease (GD) in Argentina. GD patients from 28 centers were consecutively included from April 2012 to 2014. Bone mineral density (BMD) was determined by dual X-ray absorptiometry in the lumbar spine and the femoral neck or the total proximal femur for patients â¥20âyr of age, and by whole-body scan in the lumbar spine in patients <20âyr of age. In children, mineral density was calculated using the chronological age and Z height. OP diagnosis was determined following adult and pediatric official position of the International Society for Clinical Densitometry. A total of 116 patients were included, of which 62 (53.5%) were women. The median age was 25.8âyr. All patients received enzyme replacement therapy, with a median time of 9.4âyr. Normal BMD was found in 89 patients (76.7%), whereas low bone mass (LBM) or osteopenia was found in 15 patients (13%) and OP in 12 patients (10.3%). The analysis of the pediatric population revealed that 4 patients (9.3%) had LBM and 3 (7%) had OP (Z-scoreââ¤ââ2â+âfractures height-adjusted by Z), whereas in the adult population (nâ=â73), 11 patients (15%) had LBM or osteopenia and 9 (12.3%) had OP. Bone marrow infiltration and the presence of fractures were significantly correlated with the presence of OP (pâ=â0.04 and <0.001, respectively). This is the first study in Argentina and in the region describing the frequency of OP or LBM in GD patients treated with imiglucerase using the official position of the International Society for Clinical Densitometry.
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Authors
M.S. Larroudé, G. Aguilar, I. Rossi, G. Drelichman, N. Fernandez Escobar, N. Basack, M. Slago, A. Schenone, A. Fynn, M.F. Cuello, R. Fernandez, A. Ruiz, P. Reichel, N. Guelbert, H. Robledo, N. Watman, M. Bolesina, G. Elena, F. Del Rio,